The chromatographic constitution of andiroba oil and its healing effects


Histopathological evaluation of oral mucositis at days 4, 8, 12 and 15. Credit: 2023 Gomes et al.

A new research paper titled “The Chromatographic Constitution of Andiroba Oil and Its Curative Effects, Compared to LLLT Outcomes, in Oral Mucositis Induced in Golden Syrian Hamsters: A New Treatment Option” is published in Oncotarget.

The oral mucositis is a mucosal change that usually results from oncological treatments, such as chemotherapy, and is characterized as an inflammatory process. In this new study, researchers from the Federal University of Pará and the University Center of Pará sought to demonstrate the chromatographic constitution of Andiroba oil while comparing the efficiency of andiroba oil and laser scarring in hamster oral mucositis (OM) treatments. and evaluated.

The researchers write: “The low-level laser therapy (LLLT) is the best standard treatment and the most efficient method in the treatment of OM. Likewise, the andiroba oil offers great potential for the treatment of inflammatory diseases. The healing and toxicological effects of andiroba oil, compared to the LLLT outcomes, observing whether andiroba has similar/higher potential than the LLLT.”

The animals were subjected to 5-Fluorouracil. Included in the study were 122 animals that were randomized and divided into the following groups: (a) positive control; (b) laser associated with andiroba oil; (c) laser; (d) andiroba oil; (e) negative control; (f) cyclophosphamide (genotoxicity control). The induction of oral mucositis was achieved by the administration of intraperitoneal Fluorouracil (60 mg/kg) and trauma to the mucosa.

The laser protocol was performed once a day and the andiroba oil was applied 3 times a day (1.5 ml/day). The mucosa were photographed and removed for clinical and histopathological analysis on days 4, 8, 12 and 15. The analysis was based on OM severity, in specific scores for the clinical and histopathological aspect.

Toxicity was evaluated at day 15 using the comet test and was performed by several DNA damage parameters. Data were analyzed using analysis of variance (ANOVA) Tukey post-test and Kruskal-Wallis Dunn post-test. The “andiroba oil” and “laser” groups showed better results compared to the control groups and the treatment associations. The andiroba oil showed the best results on scars, even considering its efficiency close to the laser treatment.

“Andiroba and laser alone showed no genotoxicity, but their association proves damage to DNA,” the researchers conclude.

More information:
Jessica T. Gomes et al., The chromatographic constitution of andiroba oil and its curative effects, compared with the LLLT outcomes, in oral mucositis induced in golden Syrian hamsters: a new treatment option, Oncotarget (2023). DOI: 10.18632/oncotarget.28338

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Quote: The Chromatographic Constitution of Andiroba Oil and Its Healing Effects (2023, January 24) Retrieved January 25, 2023 from

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